Even in healthy children there is a lack of calcium, developing vitamin D-deficiency. There is a method of treatment of this disease. These children in addition to drugs needs sun and a balanced diet.
In healthy children background dietary calcium deficiency, there is a D-vitamin deficiency and hypocalcemia, which are seriously affecting calcium-phosphate (CP) homeostasis and can lead to the formation of diseases and defined as premorbid state.
Vitamin D3 has a prolonged effect. When entering the body it is deposited in the liver, reticulocytes, where gradually over a period of 30 days enters the hepatocytes, where under the influence of vitamin D3-25-hydroxylase is formed by the first effective metabolite of the vitamin D3 — 25 (Oh) D3.
Medicines containing vitamin D3, which are used to correct hypocalcemia in children, is hydroxylated in the kidney to effective hormonal forms of vitamin D3. Due to the ability of vitamin a to accumulate in liver cells because of its normalizing effect is observed within 2 months after completion of the course. At this stage in the body observed the optimal ratio between the levels of effective metabolites of vitamin D3, which normalizes the synthesis of calcium binding protein, which occurs by active transport of CA in the intestine, metabolism in the cells, including bone, and helps to raise the level of CA in serum.
In children after taking a comprehensive corrective therapy, the maintenance of required components has been a steady trend towards normalization. Layering social diet and negative factors on biochemical abnormalities of mineral metabolism do not affect the main characteristics of bone tissue, namely the density and elasticity of bone. Structural bone girls practically does not differ from that of men.
The development of adaptation syndrome in children is accompanied not only by impaired mineral homeostasis, but also qualitative changes in the bone tissue in the form of osteopenia osteomalacia.
Skomprometirovana processes of bone formation in this group of children predetermines expediency of application of mineral complexes, vitamin D3 and other rehabilitation measures. To correct the damage to KF-metabolism in children at the prenosological stage with considerable effectiveness used medications of calcium in the treatment and prevention gipokaltsiemicheskogo States. In addition to medical correction, the child should always get balanced nutrition.